Trial ID: ISRCTN62305334
Other - Phase Unknown - No longer available
Background and study aims The purpose of this study is to use an additional type of picture on the MRI scanner to look into the way brain tumours (cancer that has spread to a part of the brain) behave. In particular, we are interested in using this picture to help us work out which patients develop radiotherapy damage after their treatment. We are very much hoping that the understanding that we develop in this study will lead to a larger study in future to improve the information MRI scans can yield in secondary brain tumours. Who can participate? Patients with brain metastases (secondary tumour in the brain) from a primary cancer in another part of the body who have not had previous radiotherapy to the brain or previous surgery to remove the metastasis can participate. What does the study involve? If you agree to take part, we will ask you to either sign a consent form or give verbal telephone consent. During the verbal consent process, we will fully explain the study to you including the possible risks of participation and as much time as you require to discuss any concerns or questions you have. This will be fully recorded in your medical notes and will be followed up with written consent whenever possible. When you attend for your radiotherapy planning MRI scan, our radiographers will know to take an extra picture whilst you’re having your scan. This will mean an additional 5 minutes lying down in the MRI scanner. If you consent to take part in the study, we will also collect some information in relation to your previous cancer treatment from your hospital records. All of the information that is collected will be kept anonymous and securely stored by the research team working within this study. Once you have undergone your MRI scan and completed radiotherapy, you will continue to have regular MRI scans under the care of your oncology team. For a two year period after your treatment, we will record the results of any further MRI scans that you have to assess how you have responded to radiotherapy. We may use your original MRI scans to help us in making decisions about what your future scans might show, particularly if there is a concern that you may have developed radiotherapy damage. What are the possible benefits and risks of participating? By taking part, you will be helping us to gather more information about how tumours in the brain respond to radiotherapy and who is at risk of developing radiotherapy damage. This could help guide our radiotherapy treatments in the future and improve patient care. MRI scanners don’t use radiation, so you will not experience any radiation exposure from extra time in the scanner. Some people do find MRI scanning difficult to undergo because of difficulty in small, enclosed spaces and additional time lying in the scanner could cause some people distress. Where is the study run from? Newcastle upon Tyne Hospitals NHS Foundation Trust (UK) When is the study starting and how long is it expected to run for? October 2021 to December 2025 Who is funding the study? 1. Siemens Healthcare Ltd (UK) 2. Newcastle upon Tyne Hospitals NHS Foundation Trust (UK) Who is the main contact? Dr Joanne Lewis Joanne.lewis@nhs.net
Newcastle upon Tyne Hospitals NHS Foundation Trust
Source: https://www.isrctn.com/