A Prospective, Open Label, Single Arm, Clinical Study to Evaluate the Effect of Safinamide on Sleep Quality and Polysomnographic Parameters in Patients With Parkinson's Disease: the Safe Sleep Study

Trial ID: NCT03968744

Interventional - Phase 4 - Terminated

Patients suffering of Parkinson's Disease will be treated with 50 mg/day of Safinamide per os for 2 weeks (escalation phase). Then, safinamide will be increased up to 100 mg/day and, if tolerated, the treatment will be taken for 10 more weeks (maintenance phase). Total treatment 12 weeks.

Conditions

• Idiopathic Parkinson's Disease (at Later Stage)

Interventions

• Safinamide

Eligibility

Inclusion criteria

• Age ≥ 18 years old
• Fluctuating idiopathic PD patients according to UK Brain bank Criteria
• Hoehn and Year II to IV under treatment
• Sleep disturbance with a Pittsburgh Sleep Quality Index (PSQI) \> 5
• Treatment with L-DOPA, alone or with other dopaminergic drugs, at a stable dose since at least 28 days prior to inclusion
• Treatment with all substances potentially acting on sleep and mood must be constant since at least 28 days prior to inclusion
• Written informed consent
• Willingness and ability to participate in the trial

Exclusion criteria

• Off label use of safinamide
• Early PD or absence of PD fluctuations
• Concomitant treatment with other MAO-B inhibitors (wash-out period: at least 14 days)
• Atypical Parkinsonism
• Severe known sleep-related breathing disorders with any specific treatment or severe known sleep-related breathing disorders (apnoea-hypopnea index score \>30/h) with or without a specific treatment
• Dementia (MoCA \< 26)
• Severe depression (BDI-II ≥ 29)
• Other severe psychiatric symptoms such as active psychosis or major hallucinations
• Any previous or concomitant severe medical conditions or clinical laboratory abnormality which, in the clinical judgement of the Investigators, does not allow patients' participation into the study
• Moderate or severe hepatic impairment, any type of retinopathy and/or any pathology that is deemed to be a contraindication according to safinamide's SmPC
• Any concomitant treatment not allowed or contraindicated in the safinamide SmPC
• Women who are pregnant or breast feeding
• Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration, such as oral, injectable, or implantable contraceptives, or intrauterine contraceptive devices, or who are not using any other method considered sufficiently reliable by the investigator in individual cases.

Sponsor

Alain Kaelin, Clinical Trial Unit Ente Ospedaliero Cantonale

Source: ClinicalTrials.gov

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