A Single-center Clinical Study to Evaluate the Safety and Efficacy of Autologous Bone Marrow-derived DCs(CellgramDC-WT1) and Immune Checkpoint Inhibitors in Patients With Metastatic Pancreatic Cancer Who Have Failed First-line or More Standard Chemotherapy

Trial ID: NCT06172634

Interventional - Phase 1/2 - Unknown status

To evaluate the safety and effectiveness of immune cell therapy using autologous bone marrow-derived dendritic cells and immune checkpoint inhibitors in patients with metastatic pancreatic cancer who have failed at least one standard anticancer treatment.

Conditions

• Pancreas Cancer

Interventions

• dentritic cell infusion and immunecheckpoint inhibitor

Eligibility

Inclusion criteria

• Patients histologically confirmed to have pancreatic cancer and diagnosed as recurrent or metastatic
• Patients whose disease was confirmed to have progressed according to RECIST v1.1 after 1st or more standard anticancer treatments
• Patients satisfying systemic performance status ECOG 0-2
• Patients who have not undergone surgery, radiation therapy, or immunotherapy within 4 weeks and have recovered from side effects (However, tissue collection procedures that do not affect the test subject's condition are permitted at the discretion of the researcher.)
• Patients who voluntarily agreed in writing to participate in this clinical study

Exclusion criteria

• Patients with malignant tumors other than non-melanoma skin cancer in the past 3 years
• Patients who have previously received anti-tumor immunotherapy (anti-PD1, anti-PDL-1, or CTLA4 inhibitor, etc.) or participated in clinical studies related to immunotherapy or cell therapy
• Patients with active autoimmune disease requiring systemic immunosuppressive treatment
• Patients with a history of organ or hematopoietic stem cell transplantation
• Patients with acute or chronic infection requiring systemic treatment
• Other cases where the test manager determines that it is not suitable for clinical research

Sponsor

Soonchunhyang University Hospital

Source: ClinicalTrials.gov

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