The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies

Trial ID: NCT06173934

Interventional - Phase Unknown - Unknown status

Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed of gastric emptying.

Conditions

• Diabetes

Interventions

• insulin injection 15 minutes before meals
• Insulin injection 15 minutes after eating

Eligibility

Inclusion criteria

• 1.Volunteer and sign subject informed consent prior to the trial.
• 2.Patients with type 1 diabetes, aged less than 70 years, 7%≤HbA1c≤9.0%.
• 3.There were no acute complications such as diabetic ketoacidosis and diabetic hypertonic syndrome.
• 4.Subjects were able and willing to undergo 14-day scanning blood glucose monitoring, diet and exercise routine.

Exclusion criteria

• 1.Patients with severe gastrointestinal symptoms, history of gastrointestinal disease, surgical history, or impaired liver and kidney function.
• 2.Patients who have used drugs that affect gastrointestinal function or appetite in the last week.
• 3.History of drug abuse and alcohol dependence within the past 5 years.
• 4.Systemic hormone therapy was used in the last three months.
• 5.Patients with poor compliance, irregular diet and exercise.
• 6.Patients with infection and stress within four weeks.
• 7.Patients who could not tolerate 14-day scanning blood glucose monitoring.
• 8.Patients who are pregnant, nursing or intending to become pregnant.
• 9.Any other obvious condition or comorbidities determined by the investigator: such as serious cardiopulmonary disease, endocrine disease, neurological, neoplastic, other pancreatic disease, history of mental illness.

Sponsor

Nanjing First Hospital, Nanjing Medical University

Source: ClinicalTrials.gov

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