Basic and Clinical Studies of Levodopa/Carbidopa/Entacapone in the Treatment of Early Parkinson's Disease

Trial ID: NCT06236230

Interventional - Phase 4 - Unknown status

This is a, open-label, single-arm 8-week investigation of levodopa/carbidopa/entacapone in the treatment of early Parkinson's disease.

Conditions

• Parkinson Disease

Interventions

• levodopa/carbidopa/entacapone

Eligibility

Inclusion criteria

• Male or female and greater from 30 to 80.
• Diagnosis of idiopathic PD according to the MDS PD Diagnostic Criteria (2015).
• Hoehn-Yahr stage of 1.5-3.0 ("open" stage).
• Not on anti-PD medication or stable on anti-PD medication for at least 30 days.

Exclusion criteria

• Diagnosis of atypical Parkinsonian syndrome, vascular Parkinsonism or drug-induced Parkinsonism.
• History of surgery within 6 months.
• Alcoholism, drug abuse, or severe cognitive impairment (including severe Alzheimer's disease)
• Psychiatric illness, epilepsy, pregnancy and breastfeeding, and clinically significant concomitant illnesses
• Participation in another clinical trial within 2 months.
• With dyskinesia.
• Any other condition that, in the opinion of the investigator, makes them ineligible for enrolment.

Sponsor

Second Affiliated Hospital of Soochow University

Source: ClinicalTrials.gov

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