Oxidative Stress in Children and Adolescents With Diabetic Nephropathy and the Role of Adjuvant Alpha-lipoic Acid as an Antioxidant

Trial ID: NCT06253429

Interventional - Phase 3 - Unknown status

Endothelial dysfunction in diabetes is a central event in the pathogenesis of different microangioapthic changes. Nephropathy in patients with type 1 diabetes is a severe microvascular complication.

Conditions

• Type 1 Diabetes

Interventions

• Thioctic Acid 333 MG Oral Capsule
• Captopril 25Mg Tab

Eligibility

Inclusion criteria

• Children and adolescents with type 1 diabetes
• The presence of diabetic nephropathy

Exclusion criteria

• Renal impairment due to causes other than diabetes
• Other diabetic complications than nephropathy
• Elevated liver enzymes
• Hypersensitivity to lipoic acid
• Participation in a previous investigational drug study within the 30 days preceding screening

Sponsor

Ain Shams University

Source: ClinicalTrials.gov

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