Intermediate Term Effect of Captopril on Left Ventricle Global Longitudinal Strain in Patients With Duchenne Myodystrophy

Trial ID: NCT06485661

Interventional - Phase 1 - Unknown status

To outline the intermediate term effect of prescribing Captopril as an add on therapy on Left ventricular functions as measured by Global longitudinal strain in patients with Duchenne myodystrophy (DMD)

Conditions

• Effect of Drug

Interventions

• Captopril Tablets

Eligibility

Inclusion criteria

• Genetically confirmed Duchenne myodystrophy (DMD) patients with abnormal GLS \< -18% with minimum age of 6 years old.

Exclusion criteria

• Any patient who refuses to sign an informed consent.
• Contraindication to ACEI: hypersensitivity - renal impairment - bilateral renal artery stenosis - aortic valve stenosis - hyperkalemia - hypotension.
• Reduced ejection fraction below 50%.

Sponsor

Ain Shams University

Source: ClinicalTrials.gov

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